AAP News Vol. 14 No. 5 May 1998, p. 2
© 1998 American Academy of Pediatrics
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PPROM antibiotic therapy

Stefanie Dell'Aringa

Antibiotic treatment for women with preterm premature rupture of membranes (PPROM) results in less frequent clinical amnionitis, prolonged pregnancy and reduced incidence of infant morbidity, according to a National Institute of Child Health and Human Development trial.

Researchers studied 614 women presenting with PPROM at 24 to 32 weeks' gestation. Approximately half the women received an antibiotic regimen consisting of ampicillin and erythromycin given intravenously every six hours for 48 hours. followed by an oral dose of amoxicillin and erythromycin every eight hours for five days. The remaining half received an intravenous and oral placebo regimen.