AAP News Vol. 14 No. 7 July 1998, p. 3
© 1998 American Academy of Pediatrics
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Nasal flu vaccine helps children

Carla Kemp and Luann Zanzola

A vaccine sprayed as a fine mist into children's nostrils was 93 percent effective in preventing flu and 98 percent effective in preventing flu-related ear infections, a nationwide study showed.

The multi-center, double-blind, placebo-controlled study tested live attenuated, cold-adapted, trivalent influenzavirus vaccine, administered through a nasal spray, on children ages 15 months to 71 months.

Beginning in August 1996, 288 children were enrolled to receive either a single dose of vaccine or placebo by intranasal spray, which children readily accepted. Another 1,314 received two intranasal doses approximately 60 days apart. The vaccine contained flu strains equivalent to those in the inactivated flu vaccine in use at the time.